other:
Article Title: Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Amersham ECL Anti-rabbit IgG, HRP-linked whole Ab GE Healthcare Life Sciences Cat#NA934, RRID:AB_772206 Alexa Fluor 488 donkey Anti-rabbit (IHC: 1/500) Thermo Scientific Cat#A21206, RRID:AB_141708 Alexa Fluor 594 donkey Anti-rabbit (IHC: 1/500) Thermo Scientific Cat#A21207, RRID:AB_141637 Alexa Fluor 488 goat Anti-mouse (IHC: 1/500) Thermo Scientific Cat#A21121, RRID:AB_141514 Alexa Fluor 594 goat Anti-mouse (IHC: 1/500) Thermo Scientific Cat#A21135, RRID:AB_2535774 Alexa Fluor 488 goat Anti-rat (IHC: 1/500) Thermo Scientific Cat#A11006, RRID:AB_141373 Alexa Fluor 594 goat Anti-rat (IHC: 1/500) Thermo Scientific Cat#A11007, RRID:AB_141374 ImmPRESS® HRP Anti-rabbit IgG (Peroxidase) Vector labs Cat#MP-7401, RRID:AB_2336529 ImmPRESS® HRP Anti-mouse IgG (Peroxidase) Vector labs Cat#MP-7402, RRID:AB_2336528 ImmPRESS® HRP Anti-rat IgG (Peroxidase) Vector labs Cat#MP-7444, RRID:AB_2336530 Bacterial and virus strains One Shot Stbl3 Chemically Competent E. coli Thermo Scientific Cat#C737303 Biological samples Human tumor tissue microarray (TMA) University of Bern, Institute of Pathology, Translational Research Unit N/A Chemicals, peptides, and recombinant proteins TransIT®-293 Transfection Reagent Mirus Bio Cat#MIR2705 Immobilon Forte Western HRP Substrate Millipore Cat#WBUF0500 Methyl Green Vector Labs Cat#H-3402 Annexin V-Atto 633 In house N/A Propidium Iodide (PI) Invitrogen Cat#P3566 Puromycin Gibco Cat#A11138-03 Cambritaxestat Provided by iOnctura N/A Roginolisib Provided by iOnctura N/A LPA 18:1 Sigma-Aldrich Cat#857130P DAB+ solution Dako Cat#Κ3467 M.O.M.® (Mouse on Mouse) Blocking Reagent Vector labs Cat#MKB-2213 FastSybr© green Thermo Scientific Cat#4367659 Doxycycline (1 μg/mL) Thermo Scientific Cat# BP2653 ReadyProbesTM 2.5% Normal Horse Serum Thermo Scientific Cat#R37625 Critical commercial assays KAPA HotStart Mouse Gentotyping Kit Kapa Biosystems Cat#KK7352 Proteome Profiler Human XL Cytokine Array Kit R&D Systems Cat#ARY022B Human IL-8/CXCL8 ELISA Kit - Quantikine R&D Systems Cat#D8000C cDNA Synthesis Kit Thermo Scientific Cat# K1622 Deposited data Manuscript figure source data Zenodo https://doi.org/10.5281/zenodo.18607846 Lipidomics data National Metabolomics Data Repository (NMDR) https://doi.org/10.21228/M8C268 (Continued on next page) 18 Cell Reports 45, 117188, April 28, 2026
Control:Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) ..
Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) 1 Cell culture CTRL European Normal 21 M NA NA NA NA 2 Cell culture CTRL European Normal 35 F NA NA NA NA 3* Cell culture CTRL European Normal 50 F NA NA NA NA 4 Cell culture CTRL European Normal 45 M NA NA NA NA 5* Cell culture CTRL European Normal 40 M NA NA NA NA 6* Cell culture CTRL European Normal 53 M NA NA NA NA 7 Cell culture CTRL European Normal 58 M NA NA NA NA 8 Cell culture CTRL European Normal 43 M NA NA NA NA 9* Cell culture CTRL European Normal 56 F NA NA NA NA 10 Cell culture CTRL European Normal 17 F NA NA NA NA 11 Cell culture CTRL European Normal 51 F NA NA NA NA 12 Cell culture CTRL European Normal 12 F NA NA NA NA 13 Cell culture PAH European iPAH 23 F IV Unknown Unknown 720 14* Cell culture PAH European Heritable PAH 61 F III 66 4.5 1012 15 Cell culture PAH European Heritable PAH 62 F Unknown 48 Unknown 640 16* Cell culture PAH European Heritable PAH 35 F IV 60 2.1 1920 17 Cell culture PAH European Heritable PAH 32 F IV 56 5.9 Unknown 18 Cell culture PAH European iPAH 52 M IV 51 5.7 575 19* Cell culture PAH European iPAH 39 M IV Unknown Unknown Unknown 20 Cell culture PAH European iPAH 65 M III 76 4,9 1125 21 Cell culture PAH European SSc-PAH 45 F IV 43 7.25 375 22 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 23* Cell culture PAH European iPAH 52 M IV 68 2.97 Unknown 24 Cell culture PAH European iPAH 59 M IV 66 6.47 630 25 Cell culture PAH European iPAH 40 F Unknown Unknown Unknown Unknown 26* Cell culture PAH European SSc-PAH 62 M IV 55 4.5 816 27 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 28 Cell culture PAH European Heritable PAH 26 F IV 99 Unknown Unknown 29 PCLS CTRL European Tumor resection 69 F NA NA NA NA 30 PCLS CTRL European Tumor resection 69 M NA NA NA NA 31 PCLS CTRL European Tumor resection 67 F NA NA NA NA Table S2. ..
RNA Sequencing:Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) ..
Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) 1 Cell culture CTRL European Normal 21 M NA NA NA NA 2 Cell culture CTRL European Normal 35 F NA NA NA NA 3* Cell culture CTRL European Normal 50 F NA NA NA NA 4 Cell culture CTRL European Normal 45 M NA NA NA NA 5* Cell culture CTRL European Normal 40 M NA NA NA NA 6* Cell culture CTRL European Normal 53 M NA NA NA NA 7 Cell culture CTRL European Normal 58 M NA NA NA NA 8 Cell culture CTRL European Normal 43 M NA NA NA NA 9* Cell culture CTRL European Normal 56 F NA NA NA NA 10 Cell culture CTRL European Normal 17 F NA NA NA NA 11 Cell culture CTRL European Normal 51 F NA NA NA NA 12 Cell culture CTRL European Normal 12 F NA NA NA NA 13 Cell culture PAH European iPAH 23 F IV Unknown Unknown 720 14* Cell culture PAH European Heritable PAH 61 F III 66 4.5 1012 15 Cell culture PAH European Heritable PAH 62 F Unknown 48 Unknown 640 16* Cell culture PAH European Heritable PAH 35 F IV 60 2.1 1920 17 Cell culture PAH European Heritable PAH 32 F IV 56 5.9 Unknown 18 Cell culture PAH European iPAH 52 M IV 51 5.7 575 19* Cell culture PAH European iPAH 39 M IV Unknown Unknown Unknown 20 Cell culture PAH European iPAH 65 M III 76 4,9 1125 21 Cell culture PAH European SSc-PAH 45 F IV 43 7.25 375 22 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 23* Cell culture PAH European iPAH 52 M IV 68 2.97 Unknown 24 Cell culture PAH European iPAH 59 M IV 66 6.47 630 25 Cell culture PAH European iPAH 40 F Unknown Unknown Unknown Unknown 26* Cell culture PAH European SSc-PAH 62 M IV 55 4.5 816 27 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 28 Cell culture PAH European Heritable PAH 26 F IV 99 Unknown Unknown 29 PCLS CTRL European Tumor resection 69 F NA NA NA NA 30 PCLS CTRL European Tumor resection 69 M NA NA NA NA 31 PCLS CTRL European Tumor resection 67 F NA NA NA NA Table S2. ..
Microarray:Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) ..
Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) 1 Cell culture CTRL European Normal 21 M NA NA NA NA 2 Cell culture CTRL European Normal 35 F NA NA NA NA 3* Cell culture CTRL European Normal 50 F NA NA NA NA 4 Cell culture CTRL European Normal 45 M NA NA NA NA 5* Cell culture CTRL European Normal 40 M NA NA NA NA 6* Cell culture CTRL European Normal 53 M NA NA NA NA 7 Cell culture CTRL European Normal 58 M NA NA NA NA 8 Cell culture CTRL European Normal 43 M NA NA NA NA 9* Cell culture CTRL European Normal 56 F NA NA NA NA 10 Cell culture CTRL European Normal 17 F NA NA NA NA 11 Cell culture CTRL European Normal 51 F NA NA NA NA 12 Cell culture CTRL European Normal 12 F NA NA NA NA 13 Cell culture PAH European iPAH 23 F IV Unknown Unknown 720 14* Cell culture PAH European Heritable PAH 61 F III 66 4.5 1012 15 Cell culture PAH European Heritable PAH 62 F Unknown 48 Unknown 640 16* Cell culture PAH European Heritable PAH 35 F IV 60 2.1 1920 17 Cell culture PAH European Heritable PAH 32 F IV 56 5.9 Unknown 18 Cell culture PAH European iPAH 52 M IV 51 5.7 575 19* Cell culture PAH European iPAH 39 M IV Unknown Unknown Unknown 20 Cell culture PAH European iPAH 65 M III 76 4,9 1125 21 Cell culture PAH European SSc-PAH 45 F IV 43 7.25 375 22 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 23* Cell culture PAH European iPAH 52 M IV 68 2.97 Unknown 24 Cell culture PAH European iPAH 59 M IV 66 6.47 630 25 Cell culture PAH European iPAH 40 F Unknown Unknown Unknown Unknown 26* Cell culture PAH European SSc-PAH 62 M IV 55 4.5 816 27 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 28 Cell culture PAH European Heritable PAH 26 F IV 99 Unknown Unknown 29 PCLS CTRL European Tumor resection 69 F NA NA NA NA 30 PCLS CTRL European Tumor resection 69 M NA NA NA NA 31 PCLS CTRL European Tumor resection 67 F NA NA NA NA Table S2. ..
Biomarker Discovery:Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) ..
Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) 1 Cell culture CTRL European Normal 21 M NA NA NA NA 2 Cell culture CTRL European Normal 35 F NA NA NA NA 3* Cell culture CTRL European Normal 50 F NA NA NA NA 4 Cell culture CTRL European Normal 45 M NA NA NA NA 5* Cell culture CTRL European Normal 40 M NA NA NA NA 6* Cell culture CTRL European Normal 53 M NA NA NA NA 7 Cell culture CTRL European Normal 58 M NA NA NA NA 8 Cell culture CTRL European Normal 43 M NA NA NA NA 9* Cell culture CTRL European Normal 56 F NA NA NA NA 10 Cell culture CTRL European Normal 17 F NA NA NA NA 11 Cell culture CTRL European Normal 51 F NA NA NA NA 12 Cell culture CTRL European Normal 12 F NA NA NA NA 13 Cell culture PAH European iPAH 23 F IV Unknown Unknown 720 14* Cell culture PAH European Heritable PAH 61 F III 66 4.5 1012 15 Cell culture PAH European Heritable PAH 62 F Unknown 48 Unknown 640 16* Cell culture PAH European Heritable PAH 35 F IV 60 2.1 1920 17 Cell culture PAH European Heritable PAH 32 F IV 56 5.9 Unknown 18 Cell culture PAH European iPAH 52 M IV 51 5.7 575 19* Cell culture PAH European iPAH 39 M IV Unknown Unknown Unknown 20 Cell culture PAH European iPAH 65 M III 76 4,9 1125 21 Cell culture PAH European SSc-PAH 45 F IV 43 7.25 375 22 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 23* Cell culture PAH European iPAH 52 M IV 68 2.97 Unknown 24 Cell culture PAH European iPAH 59 M IV 66 6.47 630 25 Cell culture PAH European iPAH 40 F Unknown Unknown Unknown Unknown 26* Cell culture PAH European SSc-PAH 62 M IV 55 4.5 816 27 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 28 Cell culture PAH European Heritable PAH 26 F IV 99 Unknown Unknown 29 PCLS CTRL European Tumor resection 69 F NA NA NA NA 30 PCLS CTRL European Tumor resection 69 M NA NA NA NA 31 PCLS CTRL European Tumor resection 67 F NA NA NA NA Table S2. ..
Cell Culture:Article Title: Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
Article Snippet: .. GEO series accession number Experimental design Platform PMID (publication year) GSE263226 4 control PASMC vs 5 PAH PASMC (2 IPAH, 2 heritable PAH and 1 SSc-PAH) RNA-Sequencing Present study GSE144274 4 control PASMC vs 4 IPAH PASMC RNA-Sequencing (Illumina HiSeq 4000) 32337710 (2020) Extracted from supplemental data 3 control PASMC vs 3 IPAH PASMC DNA microarray (Affymetrix Human Gene ST 1.0 chip) 25290246 (2015) # Experiment Category Ancestry Diagnosis Age Sex WHO class mPAP (mmHg) CO (L/min) PVR (dyne/sec/cm-5) 1 Cell culture CTRL European Normal 21 M NA NA NA NA 2 Cell culture CTRL European Normal 35 F NA NA NA NA 3* Cell culture CTRL European Normal 50 F NA NA NA NA 4 Cell culture CTRL European Normal 45 M NA NA NA NA 5* Cell culture CTRL European Normal 40 M NA NA NA NA 6* Cell culture CTRL European Normal 53 M NA NA NA NA 7 Cell culture CTRL European Normal 58 M NA NA NA NA 8 Cell culture CTRL European Normal 43 M NA NA NA NA 9* Cell culture CTRL European Normal 56 F NA NA NA NA 10 Cell culture CTRL European Normal 17 F NA NA NA NA 11 Cell culture CTRL European Normal 51 F NA NA NA NA 12 Cell culture CTRL European Normal 12 F NA NA NA NA 13 Cell culture PAH European iPAH 23 F IV Unknown Unknown 720 14* Cell culture PAH European Heritable PAH 61 F III 66 4.5 1012 15 Cell culture PAH European Heritable PAH 62 F Unknown 48 Unknown 640 16* Cell culture PAH European Heritable PAH 35 F IV 60 2.1 1920 17 Cell culture PAH European Heritable PAH 32 F IV 56 5.9 Unknown 18 Cell culture PAH European iPAH 52 M IV 51 5.7 575 19* Cell culture PAH European iPAH 39 M IV Unknown Unknown Unknown 20 Cell culture PAH European iPAH 65 M III 76 4,9 1125 21 Cell culture PAH European SSc-PAH 45 F IV 43 7.25 375 22 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 23* Cell culture PAH European iPAH 52 M IV 68 2.97 Unknown 24 Cell culture PAH European iPAH 59 M IV 66 6.47 630 25 Cell culture PAH European iPAH 40 F Unknown Unknown Unknown Unknown 26* Cell culture PAH European SSc-PAH 62 M IV 55 4.5 816 27 Cell culture PAH European iPAH 45 M Unknown Unknown Unknown Unknown 28 Cell culture PAH European Heritable PAH 26 F IV 99 Unknown Unknown 29 PCLS CTRL European Tumor resection 69 F NA NA NA NA 30 PCLS CTRL European Tumor resection 69 M NA NA NA NA 31 PCLS CTRL European Tumor resection 67 F NA NA NA NA Table S2. ..
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